HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5'-tert-Butoxycarbonylamino-2'-methyl-biphenyl-4-carboxylic acid ethyl ester | HCID 59822370 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid | HCID 59822348 | — |
Reaction Steps
5′-tert-Butoxycarbonylamino-2′-methyl-biphenyl-4-carboxylic acid ethyl ester (6.3 g) was stirred in ethanol (75 ml) and 1M sodium hydroxide (30 ml) at 20 C for 18 h. The mixture was then acidified and the ethanol evaporated. The pale beige solid thus formed was collected by filtration and dried (4.26 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-b7aedf9efb6847d9a24fb4e5dd7c8d98 |
| Source note | uspto-grants-2011_08 |