Triethylamine → HCID 16221916, Verbindung

HRID 1678471Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678471
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[O:10])=[CH:4][C:3]=1[C:17]1[CH:22]=[CH:21][C:20]([C:23]([OH:25])=O)=[CH:19][CH:18]=1.[O:26]=[S:27]1(=[O:41])[CH2:32][CH2:31][N:30]([CH2:33][C:34]2[CH:39]=[CH:38][C:37]([NH2:40])=[CH:36][CH:35]=2)[CH2:29][CH2:28]1.C(N(CC)CC)C.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1>CN(C=O)C>[O:41]=[S:27]1(=[O:26])[CH2:28][CH2:29][N:30]([CH2:33][C:34]2[CH:39]=[CH:38][C:37]([NH:40][C:23]([C:20]3[CH:21]=[CH:22][C:17]([C:3]4[C:2]([CH3:1])=[CH:7][CH:6]=[C:5]([NH:8][C:9]([N:11]5[CH2:12][CH2:13][O:14][CH2:15][CH2:16]5)=[O:10])[CH:4]=4)=[CH:18][CH:19]=3)=[O:25])=[CH:36][CH:35]=2)[CH2:31][CH2:32]1

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 27796824-(4-Aminobenzyl)thiomorpholine 1,1-dioxideHCID 59822395HCID 59822395, Verbindung

Produkt 1

HCID 16221916HCID 16221916, VerbindungAusbeute 48,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2′-methyl-5′-[(morpholine-4-carbonyl)-amino]-biphenyl-4-carboxylic acid (40 mg), 4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylamine (28 mg), triethylamine (0.033 ml) and O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate (67 mg) in dry DMF (3 ml) was stirred at 20 C for 18 h. The mixture was then partitioned between water and dichloromethane. The dried extracts were evaporated and the residue purified on silica gel. Elution with dichloromethane:ethanol:0.880 ammonia; 200:8:1 gave an off-white solid (32 mg).

Aufarbeitung

  1. customThe mixture was then partitioned between water and dichloromethane
  2. customThe dried extracts were evaporated
  3. customthe residue purified on silica gel
  4. washElution with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-5e980ed27bf047d5a54d3425e6e2c362
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008303B2

Notizen zur Reaktion

Wird geladen…