HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 16221916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 4-(4-Aminobenzyl)thiomorpholine 1,1-dioxide | HCID 2779682 | — |
| Reactant | HCID 59822395 | HCID 59822395 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16221916 | HCID 16221916 | 48.8% |
Reaction Steps
A mixture of 2′-methyl-5′-[(morpholine-4-carbonyl)-amino]-biphenyl-4-carboxylic acid (40 mg), 4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylamine (28 mg), triethylamine (0.033 ml) and O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate (67 mg) in dry DMF (3 ml) was stirred at 20 C for 18 h. The mixture was then partitioned between water and dichloromethane. The dried extracts were evaporated and the residue purified on silica gel. Elution with dichloromethane:ethanol:0.880 ammonia; 200:8:1 gave an off-white solid (32 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-5e980ed27bf047d5a54d3425e6e2c362 |
| Source note | uspto-grants-2011_08 |