HuagongsheHuagongshe Chemistry Print Report · For research reference only
2'-Methyl-5'-[(thiophene-2-carbonyl)-amino]-biphenyl-4-carboxylic acid ethyl ester → 2'-Methyl-5'-[(thiophene-2-carbonyl)-amino]-biphenyl-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2'-Methyl-5'-[(thiophene-2-carbonyl)-amino]-biphenyl-4-carboxylic acid ethyl ester | HCID 67372981 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2'-Methyl-5'-[(thiophene-2-carbonyl)-amino]-biphenyl-4-carboxylic acid | HCID 67373573 | — |
Reaction Steps
2′-Methyl-5′-[(thiophene-2-carbonyl)-amino]-biphenyl-4-carboxylic acid ethyl ester (425 mg) in THF (10 ml) and sodium hydroxide (1M, 20 ml) was heated to reflux for 4 h. The solvent was then evaporated and the residue acidified. The resulting precipitate was collected by filtration and dried (321 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-14f9aabed4ef4757829be62735025a58 |
| Source note | uspto-grants-2011_08 |