反应详情

2′-Methyl-5′-[(thiophene-2-carbonyl)-amino]-biphenyl-4-carboxylic acid ethyl ester (425 mg) in THF (10 ml) and sodium hydroxide (1M, 20 ml) was heated to reflux for 4 h. The solvent was then evaporated and the residue acidified. The resulting precipitate was collected by filtration and dried (321 mg).

1. temperatureto reflux for 4 h
2. customThe solvent was then evaporated
3. filtrationThe resulting precipitate was collected by filtration
4. customdried (321 mg)