Trifluoroacetic acid → HCID 59822389, compound

HRID 1678478Notes

Reaction equation

HRID 1678478 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]([C:19]2[CH:24]=[CH:23][C:22]([C:25](=[O:42])[NH:26][C:27]3[CH:32]=[CH:31][C:30]([CH2:33][N:34]4[CH2:39][CH2:38][S:37](=[O:41])(=[O:40])[CH2:36][CH2:35]4)=[CH:29][CH:28]=3)=[CH:21][CH:20]=2)[C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:12][CH:13]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[O:41]=[S:37]1(=[O:40])[CH2:38][CH2:39][N:34]([CH2:33][C:30]2[CH:29]=[CH:28][C:27]([NH:26][C:25]([C:22]3[CH:23]=[CH:24][C:19]([C:10]4[CH:9]=[C:8]([NH2:7])[CH:13]=[CH:12][C:11]=4[O:14][C:15]([F:18])([F:16])[F:17])=[CH:20][CH:21]=3)=[O:42])=[CH:32][CH:31]=2)[CH2:35][CH2:36]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59822367HCID 59822367, compound

Product 1

HCID 59822389HCID 59822389, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

{4′-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylcarbamoyl]-6-trifluoromethoxy-biphenyl-3-yl}-carbamic acid tert-butyl ester (140 mg) was stirred in 1:1 trifluoroacetic acid:dichloromethane (6 ml) at 20 C for 1 h. The mixture was then basified and extracted with ethyl acetate. The dried extracts were then evaporated giving a dark gum (105 mg).

Workup

  1. extractionextracted with ethyl acetate
  2. customThe dried extracts were then evaporated

Sources & evidence

ORD record
ord-7218b1cbb6fc4f3585b64f4eac510075
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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