Hydrochloric Acid → 5'-Amino-2'-chloro-biphenyl-4-carboxylic acid ethyl ester hydrochloride

HRID 1678486Notes

Reaction equation

HRID 1678486 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:13]=2[Cl:21])=[CH:8][CH:7]=1)=[O:5])[CH3:2].Cl>C(O)C>[ClH:21].[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:13]=2[Cl:21])=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 598223932'-Chloro-5'-nitro-biphenyl-4-carboxylic acid ethyl ester

Product 1

HCID 673717565'-Amino-2'-chloro-biphenyl-4-carboxylic acid ethyl ester hydrochlorideYield 192.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2′-Chloro-5′-nitro-biphenyl-4-carboxylic acid ethyl ester (1.04 g) in ethanol 30 ml) and 2M HCl (5.0 ml) was hydrogenated at RTP for 3 h. The mixture was then filtered through celite and the solvent evaporated to give the title compound as a dark red solid (1.02 g) which was used in the next stage without further purification.

Workup

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-bc3e3e401b7e46ad99bced5cb28db57e
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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