5'-(Cyclohexanecarbonyl-amino)-2'-chloro-biphenyl-4-carboxylic acid ethyl ester → 2'-Chloro-5'-(cyclohexanecarbonyl-amino)-biphenyl-4-carboxylic acid

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Reaction Steps

A mixture of 5′-(cyclohexanecarbonyl-amino)-2′-chloro-biphenyl-4-carboxylic acid ethyl ester (200 mg) in ethanol (15 ml) and 1M sodium hydroxide (7.5 ml) was stirred at 20 C for 18 h. The ethanol was then evaporated and the residue acidified. The solid thus formed was collected by filtration and dried (176 mg).

Provenance & Evidence