HCID 59822356, compound → HCID 59822333, compound

HRID 1678491Notes

Reaction equation

HRID 1678491 reaction equation
[O:1]=[S:2]1(=[O:33])[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([C:18]3[CH:23]=[CH:22][C:21]([C:24]4[CH:29]=[C:28]([CH2:30][OH:31])[CH:27]=[CH:26][C:25]=4[CH3:32])=[CH:20][CH:19]=3)=[O:17])=[CH:11][CH:10]=2)[CH2:4][CH2:3]1>ClCCl.[O-2].[O-2].[Mn+4]>[O:33]=[S:2]1(=[O:1])[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([C:18]3[CH:19]=[CH:20][C:21]([C:24]4[CH:29]=[C:28]([CH:30]=[O:31])[CH:27]=[CH:26][C:25]=4[CH3:32])=[CH:22][CH:23]=3)=[O:17])=[CH:11][CH:10]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 59822356HCID 59822356, compound

Product 1

HCID 59822333HCID 59822333, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

5′-Hydroxymethyl-2′-methyl-biphenyl-4-carboxylic acid [4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenyl]-amide (500 mg) in dichloromethane (30 ml) was treated with manganese dioxide (3 g) and the mixture stirred at 20 C for 18 h. The suspension was then filtered through celite and the mother liquor evaporated giving the title compound as a colourless oil (480 mg)

Workup

  1. filtrationThe suspension was then filtered through celite
  2. customthe mother liquor evaporated

Sources & evidence

ORD record
ord-da28510bcbf54691a54689ca437c1c4d
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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