3-Nitro-4-(trifluoromethoxy)benzoic acid → 3-Amino-4-(trifluoromethoxy)benzoic acid

HRID 1678523Notes

Reaction equation

HRID 1678523 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][C:14]([F:17])([F:16])[F:15])[C:7]([OH:9])=[O:8])([O-])=O>CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][C:14]([F:15])([F:16])[F:17])[C:7]([OH:9])=[O:8]

Participants

3

Reactant 1

HCID 186262173-Nitro-4-(trifluoromethoxy)benzoic acid

Product 1

HCID 202740943-Amino-4-(trifluoromethoxy)benzoic acidYield 97.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-nitro-4-trifluoromethoxybenzoic acid (3 g) in methanol (240 ml) was hydrogenated at 50° C. and 50 bar using H-cube apparatus. The methanol solution was evaporated giving the title compound as a white solid (2.58 g).

Workup

  1. customwas hydrogenated at 50° C.
  2. customThe methanol solution was evaporated

Sources & evidence

ORD record
ord-ebfd23b88677408e80c4208b95b8ebd6
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

Loading…