反应详情

A mixture of ethyl 3-fluoro-4-[(2,4,6-trimethylphenyl)methoxy]benzenepropanoate (363 mg, 1.1 mmol), a 2 N aqueous sodium hydroxide solution (1.5 mL) and ethanol (5 mL) was stirred at 60° C. for 1.5 hours. The reaction solution was ice-cooled and acidified with 1 N hydrochloric acid, and then the solvent was distilled off under reduced pressure. The residue was dissolved in methylene chloride, and the mixture was washed with water and saturated brine and dried over magnesium sulfate. Then, the solvent was distilled off under reduced pressure, and the resulting crystals were recrystallized from ethyl acetate/hexane (190 mg, yield 57%).

1. temperaturecooled
2. distillationthe solvent was distilled off under reduced pressure
3. dissolutionThe residue was dissolved in methylene chloride
4. washthe mixture was washed with water and saturated brine
5. dry with materialdried over magnesium sulfate
6. distillationThen, the solvent was distilled off under reduced pressure