Sodium Hydroxide → [2-(4-Chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-cyclohexyl-acetic acid

HRID 1678621Notes

Reaction equation

HRID 1678621 reaction equation
C([O:3][C:4](=[O:28])[CH:5]([C:12]1[N:13]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[N:14]=[C:15]2[C:20]=1[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)C.[OH-].[Na+]>CO>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([N:13]2[C:12]([CH:5]([CH:6]3[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]3)[C:4]([OH:28])=[O:3])=[C:20]3[C:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)=[N:14]2)=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67131110[2-(4-Chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-cyclohexyl-acetic acid ethyl ester

Product 1

HCID 67131112[2-(4-Chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-cyclohexyl-acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In analogy to the procedure described in example 4.5, [2-(4-chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-cyclohexyl-acetic acid ethyl ester (example 4.3) was treated with aqueous NaOH solution in MeOH to give the title compound as yellow foam which was sufficiently pure to be used in the next step. MS: m/e=373.2 [M+H+].

Sources & evidence

ORD record
ord-9bae19ce1ddc42bfae546ad950289937
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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