反应详情

Borane-tetrahydrofuran complex (680 ul, 680 umol; 1 M solution in THF) was added to an ice cold solution of [rac]-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-cyclohexyl-acetic acid (100 mg, 270 umol; example 4.5) in THF (1 ml). The solution was stirred at ambient temperature for 14 h. The solvent was removed under reduced pressure and the residue purified by preparative thin layer chromatography (silica gel, iPrOAc/heptane) to obtain the title compound (56 mg, 160 umol; 58%) as colorless foam. MS: m/e=355.3 [M+H+].

1. customThe solvent was removed under reduced pressure
2. customthe residue purified by preparative thin layer chromatography (silica gel, iPrOAc/heptane)