反应详情

To a solution of [rac]-4-{(E)-3-[2-(4-chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-3-cyclohexyl-propenyl}-benzoic acid (0.227 mmol; example 67.3) in 3 ml EtOAc was added 30 mg Pd (5%) on charcoal. 3 ml MeOH was added. The reaction mixture was vigorously stirred at room temperature under 1.5 bar H2 pressure for 1 hours. The reaction mixture was filtrated over dicalite and concentrated under vacuum. The residue was purified by preparative HPLC to give the title compound.

1. filtrationThe reaction mixture was filtrated over dicalite
2. concentrationconcentrated under vacuum
3. customThe residue was purified by preparative HPLC