Hydrogen chloride-ethyl acetate → Hydrochloric Acid

Participants

Reaction Steps

A 4 mol/L hydrogen chloride-ethyl acetate solution (70 mL; manufactured by Kokusan Chemical Co., Ltd.) was added to (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)methylsulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-ethylindazole-1-carboxylate (3.56 g) that can be produced by the method described in Reference Example 15 or the like, and the mixture was stirred overnight at room temperature. Precipitates were filtered, and the Solids were washed five times with ethyl acetate (3 mL) and once with diethyl ether (1 mL). Thus, the title compound was obtained in the form of hydrochloride (2.056 g).

Provenance & Evidence