Hydrogen chloride-ethyl acetate → Hydrochloric Acid

HRID 1678705Notes

Reaction equation

HRID 1678705 reaction equation
C(OC([N:8]([CH2:30][C@@H:31]([C:40]1[CH:45]=[CH:44][CH:43]=[C:42]([N:46](C(OC(C)(C)C)=O)[S:47]([CH3:50])(=[O:49])=[O:48])[CH:41]=1)[O:32][Si](CC)(CC)CC)[CH2:9][CH2:10][O:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH2:28][CH3:29])=[N:17][N:18]2C(OC(C)(C)C)=O)=[CH:14][CH:13]=1)=O)(C)(C)C.C(OCC)(=O)C.[ClH:64]>>[OH:32][C@H:31]([C:40]1[CH:41]=[C:42]([NH:46][S:47]([CH3:50])(=[O:48])=[O:49])[CH:43]=[CH:44][CH:45]=1)[CH2:30][NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH2:28][CH3:29])=[N:17][NH:18]2)=[CH:14][CH:13]=1.[ClH:64]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59373785HCID 59373785, compound

Product 2

HCID 313Hydrochloric AcidHCID 178438017HCID 178438017, compound

Procedure

A 4 mol/L hydrogen chloride-ethyl acetate solution (70 mL; manufactured by Kokusan Chemical Co., Ltd.) was added to (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)methylsulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-ethylindazole-1-carboxylate (3.56 g) that can be produced by the method described in Reference Example 15 or the like, and the mixture was stirred overnight at room temperature. Precipitates were filtered, and the Solids were washed five times with ethyl acetate (3 mL) and once with diethyl ether (1 mL). Thus, the title compound was obtained in the form of hydrochloride (2.056 g).

Workup

  1. customcan be produced by the method
  2. customPrecipitates
  3. filtrationwere filtered
  4. washthe Solids were washed five times with ethyl acetate (3 mL)

Sources & evidence

ORD record
ord-25650c1b32bf4ce2a879304116678f45
Source dataset
uspto-grants-2011_08
Patent number
US08008506B2

Reaction notes

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