6-Methoxy-1H-indazole-3-carboxylic acid → 6-Hydroxy-1H-indazole-3-carboxylic acid

HRID 1678712Notes

Reaction equation

HRID 1678712 reaction equation
C[O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:12]([OH:14])=[O:13])=[N:8][NH:9]2)=[CH:5][CH:4]=1>Br>[OH:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:12]([OH:14])=[O:13])=[N:8][NH:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 224776586-Methoxy-1H-indazole-3-carboxylic acid

Product 1

HCID 1356270846-Hydroxy-1H-indazole-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

6-Methoxyindazole-3-carboxylic acid (1.015 g; manufactured by ChemPacific Corp.) was dissolved in hydrobromic acid (52 mL; manufactured by Kanto Chemical Co., Inc.), and the solution was stirred overnight at reflux. The solution was cooled to room temperature, and then the loss of raw materials and the presence of the title compound were confirmed using LCMS. The solvent was evaporated under reduced pressure, and thus a crude product (1.504 g) of the title compound was obtained.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-f33be6d1ca174b2a959756ac780b6124
Source dataset
uspto-grants-2011_08
Patent number
US08008506B2

Reaction notes

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