Water → HCID 135929580, compound

HRID 1678714Notes

Reaction equation

HRID 1678714 reaction equation
O.C([O:9][C:10]1[CH:18]=[C:17]2[C:13]([C:14]([CH2:25][O:26][CH3:27])=[N:15][N:16]2[CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][O:20]2)=[CH:12][CH:11]=1)C1C=CC=CC=1>[Pd].C1COCC1>[CH3:27][O:26][CH2:25][C:14]1[C:13]2[C:17](=[CH:18][C:10]([OH:9])=[CH:11][CH:12]=2)[N:16]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][O:20]2)[N:15]=1

Participants

5

Reactant 2

HCID 962WaterHCID 59373815HCID 59373815, compound

Product 1

HCID 135929580HCID 135929580, compoundYield 100.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

5% Palladium on carbon-STD-type-50% wet with water (199 mg; manufactured by N.E. Chemcat Corp.) and 6-(benzyloxy)-3-(methoxymethyl)-1-(tetrahydro-2H-pyran-2-yl)indazole (450 mg) that can be produced by the method described in Reference Example 54 or the like, were dissolved in THF (12.7 mL; manufactured by Kanto Chemical Co., Inc.). The reaction system was purged with hydrogen, and under a hydrogen atmosphere, the reaction solution was stirred overnight at room temperature. The reaction solution was purged with nitrogen, and then was filtered. The filtrate was concentrated under reduced pressure, and thus the title compound (337.4 mg) was obtained.

Workup

  1. customcan be produced by the method
  2. customThe reaction system was purged with hydrogen
  3. customThe reaction solution was purged with nitrogen
  4. filtrationwas filtered
  5. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-10a06dbcc1f946a7bd9c9a6325644b50
Source dataset
uspto-grants-2011_08
Patent number
US08008506B2

Reaction notes

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