6-Methoxypyridine-3-carbaldehyde → HCID 178519721, compound

HRID 1678785Notes

Reaction equation

HRID 1678785 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[O:10])=[CH:5][CH:4]=1>Cl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[CH:7][N:8]=1

Participants

3

Reactant 1

HCID 33645766-Methoxypyridine-3-carbaldehyde

Product 1

HCID 178519721HCID 178519721, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A stirred solution of 6-methoxy-3-pyridinecarboxaldehyde (0.45 g, 3.3 mMol) in 3N HCl (10 mL) was heated to 100° C. for 30 minutes. Upon cooling, needle-like crystals developed. The crystals were collected via filtration to yield 17-2. 1H-NMR (CD3OD) δ 9.64 (s, 1H), δ 8.17-8.16 (m, 1H), S 7.96-7.94 (m, 1H), δ 6.58 (d, 1H).

Workup

  1. temperatureUpon cooling
  2. filtrationThe crystals were collected via filtration
  3. customto yield 17-2

Sources & evidence

ORD record
ord-eb770190496945b397b8c5fe60ecf450
Source dataset
uspto-grants-2011_08
Patent number
US08008317B2

Reaction notes

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