Sodium hydrosulfide → HCID 178469947, compound

HRID 1678852Notes

Reaction equation

HRID 1678852 reaction equation
Cl[C:2]1[C:3]2[N:4]([N:13]=[CH:14][C:15]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:5]2[N:10]([CH3:11])[N:9]=[C:8]([CH3:12])[C:6]=2[N:7]=1.[SH-:21].[Na+]>C(O)CC>[CH3:11][N:10]1[C:5]2[N:4]3[N:13]=[CH:14][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:3]3[C:2]([SH:21])=[N:7][C:6]=2[C:8]([CH3:12])=[N:9]1

Participants

4

Reactant 2

HCID 28015Sodium hydrosulfideHCID 539664075-Chloro-1,3-dimethyl-1H-dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, ethyl ester

Product 1

HCID 178469947HCID 178469947, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

5.86 gms. of 5-chloro-1,3-dimethyl-1H-dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, ethyl ester, are refluxed with 2 gms. of sodium bisulfide and 50 ml. of n-propanol for 3 hours. On cooling, the product, 1,3-dimethyl-5-mercapto-1H-dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, ethyl ester, crystallizes in the form of yellow filamentous needles which are recrystallized from n-propanol, yield 4.76 gms., m.p. 189°-191°.

Workup

  1. temperatureOn cooling
  2. customthe product, 1,3-dimethyl-5-mercapto-1H-dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, ethyl ester, crystallizes in the form of yellow filamentous needles which
  3. customare recrystallized from n-propanol, yield 4.76 gms

Sources & evidence

ORD record
ord-8c218b7a302e497e9b86ae99aa9b64fb
Source dataset
uspto-grants-1978_03
Patent number
US04077956

Reaction notes

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