Hydrochloric Acid → HCID 178433928, compound

HRID 1678853Notes

Reaction equation

[OH:1][C:2]1[C:3]2[N:4]([N:13]=[CH:14][C:15]=2[C:16]([O:18]CC)=[O:17])[C:5]2[N:10]([CH3:11])[N:9]=[C:8]([CH3:12])[C:6]=2[N:7]=1.Cl>>[OH:1][C:2]1[C:3]2[N:4]([N:13]=[CH:14][C:15]=2[C:16]([OH:18])=[O:17])[C:5]2[N:10]([CH3:11])[N:9]=[C:8]([CH3:12])[C:6]=2[N:7]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 178469946HCID 178469946, compound

Product 1

HCID 178433928HCID 178433928, compound

Procedure

2.75 gms. of 5-hydroxy-1,3-dimethyl-1H-dipyrazolo-[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, ethyl ester are suspended in 20 ml. of concentrated hydrochloric acid. On warming, a clear solution results from which the product, 5-hydroxy-1,3-dimethyl-1H-dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, precipitates after 40 minutes as a crystal-like mass. The product is purified by dissolving the precipitate in concentrated ammonia solution, treating with charcoal, reprecipitating with hydrochloric acid and recrystallizing from dimethylformamide, m.p. > 300°.

Workup

temperatureOn warming

Sources & evidence

ORD record: ord-8d66e03dabe8428f8e8751302c6a5530
Source dataset: uspto-grants-1978_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04077956

Reaction notes

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