反应详情

5 g of cyclohexanone oxime, 1 g of potassium hydroxide, 50 ml of dimethylsulfoxide and 50 ml of dioxane are heated for a period of one hour at the temperature of 140° C in the presence of a 5-fold excess of acetylene (with respect to the stoichiometric amount thereof). After extraction with diethyl ether and distillation 5.4 g (yield is 91.6%) of 1-vinyl-4,5,6,7-tetrahydroindole are obtained.

1. extractionAfter extraction