HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 1-Vinyl-4,5,6,7-tetrahydroindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Acetylene | HCID 6326 | — |
| Reactant | Cyclohexanone Oxime | HCID 7517 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Vinyl-4,5,6,7-tetrahydroindole | HCID 11159388 | 91.6% |
Reaction Steps
5 g of cyclohexanone oxime, 1 g of potassium hydroxide, 50 ml of dimethylsulfoxide and 50 ml of dioxane are heated for a period of one hour at the temperature of 140° C in the presence of a 5-fold excess of acetylene (with respect to the stoichiometric amount thereof). After extraction with diethyl ether and distillation 5.4 g (yield is 91.6%) of 1-vinyl-4,5,6,7-tetrahydroindole are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04077975 |
| Source dataset | uspto-grants-1978_03 |
| ORD ID | ord-9cff0faa917246d8b95adbf38e874681 |
| Source note | uspto-grants-1978_03 |