Hydrochloric Acid → HCID 178479189, compound

HRID 1678906Notes

Reaction equation

HRID 1678906 reaction equation
C([NH:4][CH2:5][C:6]1[S:10][C:9]([SH:11])=[N:8][N:7]=1)(=O)C.[ClH:12]>>[ClH:12].[NH2:4][CH2:5][C:6]1[S:10][C:9]([SH:11])=[N:8][N:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178474654HCID 178474654, compound

Product 1

HCID 178479189HCID 178479189, compound

Procedure

Thus obtained 5-acetamidomethyl-1,3,4-thiadiazole-2-thiol (44 g) was suspended in 6N hydrochloric acid (400 ml) and the mixture was heated to reflux for 2 hours. The reaction mixture was allowed to cool, and the precipitates were collected by filtration and washed with ethanol to give 5-aminomethyl-1,3,4-thiadiazole-2-thiol hydrochloride (28.3 g). m.p. 213° to 217° C. The mother liquid obtained above was concentrated under reduced pressure and the residue was washed with ether to give the same objective product (12.6 g). Total yield is 40.9 g.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 2 hours
  3. temperatureto cool
  4. filtrationthe precipitates were collected by filtration
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-048bb7ea113e485dbd360c293ae1a877
Source dataset
uspto-grants-1978_03
Patent number
US04077965

Reaction notes

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