Glycerol → HCID 13445971, compound

HRID 1678991Notes

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[OH:15][CH2:16][CH:17]([CH2:19]O)[OH:18]>>[OH:18][CH:17]1[CH2:16][O:15][CH:6]([C:5]2[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][CH:4]=2)[O:7][CH2:19]1

Participants

Reactant 3

HCID 753Glycerol

HCID 1118Sulfuric Acid

HCID 77264-Chlorobenzaldehyde

Product 1

HCID 13445971HCID 13445971, compound

Procedure

Using the method of Example 21, 42 g 4-chlorobenzaldehyde, 27.6 g glycerol and 4 ml 40 percent sulfuric acid were reacted to form 5-hydroxy-2-(4-chlorophenyl)-1,3-dioxane. The reaction mixture was dissolved in benzene and washed successively with two 50 ml volumes of 5 percent aqueous sodium bicarbonate, two 50 ml volumes aqueous sodium bisulfite and two 100 ml volumes of water. The benzene solution was dried with magnesium sulfate, filtered and evaporated under reduced pressure to form an oil which crystallized, m.p. 95°-100° C (recrystallized from benzene-ligroin).

Workup

customwere reacted

Sources & evidence

ORD record: ord-0918f3b35da549af9e4c63d5db732199
Source dataset: uspto-grants-1978_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04077982

Reaction notes

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