3-Fluorobenzaldehyde → HCID 20364907, compound

HRID 1679020Notes

Reaction equation

HRID 1679020 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[F:10][C:11]1[CH:24]=[CH:23][CH:22]=[CH:21][C:12]=1[CH2:13][O:14][C:15]([CH3:20])([CH3:19])[CH:16](O)[OH:17]>C1C=CC=CC=1>[F:10][C:11]1[CH:24]=[CH:23][CH:22]=[CH:21][C:12]=1[CH2:13][O:14][C:15]1([CH3:20])[CH2:16][O:17][CH:5]([C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=2)[O:6][CH2:19]1

Participants

4

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 20364996HCID 20364996, compound

Product 1

HCID 20364907HCID 20364907, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Using the procedure of Example 51, 3-fluorobenzaldehyde and 2-(2-fluorobenzyloxy)-2-methylpropanediol were reacted, using benzene as solvent, to give, after separation by column chromatography, c-5-(2-fluorobenzyloxy)-r-2-(3-fluorophenyl)-5-methyl1,3-dioxane, m.p. 86°-87°, and t-5-(2-fluorobenzyloxy)-r-2-(3-fluorophenyl)-5-methyl-1,3-dioxane, m.p. 83°-84°.

Workup

  1. customwere reacted
  2. customto give
  3. customafter separation by column chromatography, c-5-(2-fluorobenzyloxy)-r-2-(3-fluorophenyl)-5-methyl1,3-dioxane, m.p. 86°-87°, and t-5-(2-fluorobenzyloxy)-r-2-(3-fluorophenyl)-5-methyl-1,3-dioxane, m.p. 83°-84°

Sources & evidence

ORD record
ord-73b0a3ed1df0498ba1b63dd21e79a872
Source dataset
uspto-grants-1978_03
Patent number
US04077982

Reaction notes

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