2-Thiophenecarboxaldehyde → HCID 70624710, compound

HRID 1679021Notes

Reaction equation

HRID 1679021 reaction equation
[S:1]1C=C[CH:3]=[C:2]1[CH:6]=[O:7].[F:8][C:9]1[CH:22]=[CH:21][CH:20]=[CH:19][C:10]=1[CH2:11][O:12][C:13]([CH3:18])([CH2:16]O)CO>C1C=CC=CC=1>[F:8][C:9]1[CH:22]=[CH:21][CH:20]=[CH:19][C:10]=1[CH2:11][O:12][C:13]1([CH3:18])[S:1][CH:2]([CH:6]2[O:7][CH2:3][CH2:2][CH2:6][O:7]2)[CH:3]=[CH:16]1

Participants

4

Reactant 2

HCID 73642-ThiophenecarboxaldehydeHCID 20364943HCID 20364943, compound

Product 1

HCID 70624710HCID 70624710, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Using the procedure of Example 51, thiophene-2-carboxaldehyde and 2-(2-fluorobenzyloxy)-2-methyl-1,3-propanediol were reacted, using benzene as solvent, to give, after separation by column chromatograph, c-5-(2-fluorobenzyloxy)-5-methyl-r-2-thienyl-1,3-dioxane, m.p. 111°-112°, and t-5-(2-fluorobenzyloxy)-5-methyl-r-2-thienyl-1,3-dioxane, m.p. 84°-85°.

Workup

  1. customwere reacted
  2. customto give
  3. customafter separation by column chromatograph, c-5-(2-fluorobenzyloxy)-5-methyl-r-2-thienyl-1,3-dioxane, m.p. 111°-112°, and t-5-(2-fluorobenzyloxy)-5-methyl-r-2-thienyl-1,3-dioxane, m.p. 84°-85°

Sources & evidence

ORD record
ord-70b7c6ae79524a20a5c946ea1504f8c5
Source dataset
uspto-grants-1978_03
Patent number
US04077982

Reaction notes

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