Methanol → 4-(4-Chloro-2-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 167907Notes

Reaction equation

HRID 167907 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:21](=[O:22])[OH:23])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH3:24][Si:25]([CH:26]=[N+:27]=[N-:28])([CH3:29])[CH3:30].[CH3:31][OH:32].[c:33]1([CH3:34])[cH:35][cH:36][cH:37][cH:38][cH:39]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:21](=[O:22])[O:23][CH3:24])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 887MethanolHCID 1140TolueneHCID 167693TrimethylsilyldiazomethaneHCID 665995652-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-chlorobenzoic acid

Product 1

HCID 667586124-(4-Chloro-2-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-468d34e77ac1412286f9e091d47bcead
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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