Hydrochloric Acid → HCID 178479820, compound

HRID 1679093Notes

Reaction equation

HRID 1679093 reaction equation
Cl.[Cl:2][C:3]1[CH:20]=[CH:19][C:6]([NH:7][C:8]2[NH:17][C:16](=[S:18])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)=[CH:5][CH:4]=1>COCCO>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([NH:7][C:8]2[NH:17][C:16](=[S:18])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178527904HCID 178527904, compound

Product 1

HCID 178479820HCID 178479820, compoundYield 189.3%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Concentrated hydrochloric acid (2 ml.) was added to a hot solution of 2-(4-chloroanilino)quinazoline-4(3H)-thione (1.5 g.) in 2-methoxyethanol (30 ml.). The precipitate was collected, washed with cold 2-methoxyethanol, and dried to give the title compound (1.6 g., 95%), m.p. 267°-274°.

Workup

  1. customThe precipitate was collected
  2. washwashed with cold 2-methoxyethanol
  3. customdried

Sources & evidence

ORD record
ord-7b907a07f5724a47bcf530bcd07f4b22
Source dataset
uspto-grants-1978_03
Patent number
US04079057

Reaction notes

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