Acetic Anhydride → HCID 86732955, compound

HRID 1679163Notes

Reaction equation

HRID 1679163 reaction equation
C(O[C:5](=[O:7])C)(=O)C.[C:8]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:13]=[CH:12][C:11]([C:14]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[CH:15][CH2:16][NH2:17])=[CH:10][CH:9]=1>C(O)=O>[C:21]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:20]=[CH:19][C:18]([C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:9][CH:10]=2)=[CH:15][CH2:16][NH:17][CH:5]=[O:7])=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20363851HCID 20363851, compound

Product 1

HCID 86732955HCID 86732955, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Acetic anhydride (1ml) was added to a solution of 1, 1 -di(4-biphenylyl)- 3 -amino-prop-1-ene (1g) in 99% formic acid (5ml) and the mixture was refluxed for 1 hour then poured onto ice. The solid was collected, washed with water, dried and then recrystallised from benzene/ n - propanol to furnish 1, 1-di (4 -biphenyly)-3-formamido-prop-1-ene (m.p. 171°- 173° C). This compound, reduced with lithium aluminium/hydride in ether/tetrahydrofuran at - 30° C, afforded 1, 1-di(4-biphenylyl)-3-methylamino-prop- 1-ene identical with that described in Example 4.

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. additionthen poured onto ice
  3. customThe solid was collected
  4. washwashed with water
  5. customdried
  6. customrecrystallised from benzene/ n - propanol

Sources & evidence

ORD record
ord-4d51147986644ef8ad861c022263682a
Source dataset
uspto-grants-1978_03
Patent number
US04079081

Reaction notes

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