反应详情

18.7 g (0.06 mole) of 3-chloro-4-(3-trifluoromethylphenoxy)-aniline were dissolved in 100 ml of acetonitrile, and 3 drops of triethylamine and 4.3 g (0.078 mole) of methylisocyanate were added at 10° C. The mixture was stirred for a further 4 hours at room temperature and then poured into water, and when the reaction mixture had crystallized throughout the solid was filtered off and recrystallized from toluene. 6 g (29% of theory) of N-methyl-N'-[3-chloro-4-(3-trifluoromethylphenoxy)-phenyl]-urea of melting point 160° C were obtained.

1. customhad crystallized throughout the solid
2. filtrationwas filtered off
3. customrecrystallized from toluene