Water → HCID 20362105, compound

HRID 1679248Notes

Reaction equation

HRID 1679248 reaction equation
[C:1]([NH:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:16](O)([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:15][S:14][C:13]2=[S:24])=[CH:8][CH:7]=1)(=[O:3])[CH3:2].O>Cl.CO>[C:1]([NH:4][NH:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[C:16]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:15][S:14][C:13]2=[S:24])=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 962WaterHCID 20362127HCID 20362127, compound

Product 1

HCID 20362105HCID 20362105, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

3-[4-(2-Acetylhydrazino)phenyl]-4-hydroxy-4-phenyl-thiazolidine-2-thione (1.0 g, 0.0028 mole) was added to water (25 ml) and methanol (5 ml). Concentrated hydrochloric acid (2 drops) was added; and the resulting mixture was stirred and heated at 80° C for 3 hours. The reaction mixture was chilled in ice, and the solid was filtered off. The product was washed with water, then ether, and allowed to dry. Yield 0.80 g (84%), m.p. 230°-232° C.

Workup

  1. temperatureThe reaction mixture was chilled in ice
  2. filtrationthe solid was filtered off
  3. washThe product was washed with water
  4. customto dry

Sources & evidence

ORD record
ord-630cf4e767964a569519e59e27d11796
Source dataset
uspto-grants-1978_03
Patent number
US04080207

Reaction notes

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