HCID 178463890, compound → HCID 178463877, compound

HRID 1679267Notes

Reaction equation

HRID 1679267 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8]C(O)=O)[N:5]=[C:4]([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[N:3]=1>C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:12]([CH2:13][CH3:14])[CH2:15][CH3:16])[N:3]=1

Participants

3

Reactant 1

HCID 178463890HCID 178463890, compound

Product 1

HCID 178463877HCID 178463877, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Hydroxy-2-diethylaminopyrimidin-6-yl acetic acid (4.0 g) was suspended in ethanol (50 ml) and the mixture refluxed for 16 hours. The volatile portion of the mixture was then evaporated under reduced pressure to yield 4-hydroxy-2-diethylamino-6-methyl pyrimidine as a white powder, melting at 135° C.

Workup

  1. temperaturethe mixture refluxed for 16 hours
  2. customThe volatile portion of the mixture was then evaporated under reduced pressure

Sources & evidence

ORD record
ord-3f7a19b4e9aa45d08b52f63ed0edecf2
Source dataset
uspto-grants-1978_03
Patent number
US04080326

Reaction notes

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