Ammonia → HCID 20362465, compound

HRID 1679301Notes

Reaction equation

HRID 1679301 reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]1[CH:14]=[C:13]([C:15]([O:17]CC)=O)[O:12][N:11]=1.[NH3:20]>CO>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]1[CH:14]=[C:13]([C:15](=[O:17])[NH2:20])[O:12][N:11]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20362475HCID 20362475, compound

Product 1

HCID 20362465HCID 20362465, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3 g. of the compound prepared in Example 12 is dissolved in hot methanol. The solution is saturated with ammonia. A precipitate is formed and the mixture is cooled by placing in the refrigerator. After filtration and purification, the pure product having a melting point of 235°-238° C. is recovered. This product is identified as 1-methyl-2-(5-carbamoyl-isoxazol-3-yl)-5-nitroimidazole.

Workup

  1. customA precipitate is formed
  2. temperaturethe mixture is cooled
  3. filtrationAfter filtration and purification
  4. customis recovered

Sources & evidence

ORD record
ord-d0f2be22405447b1a9cc1508d70e59e4
Source dataset
uspto-grants-1978_03
Patent number
US04080340

Reaction notes

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