Hydrochloric Acid → HCID 22754231, compound

HRID 1679344Notes

Reaction equation

HRID 1679344 reaction equation
F[C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[CH3:16][O-:17].[Na+].Cl>CO.O>[CH3:16][O:17][C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 22754232HCID 22754232, compound

Product 1

HCID 22754231HCID 22754231, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 11.05 grams (0.05 mole) of 4-((6-fluoro-2-pyridyl)thio)phenol (prepared as above in Example VI) and 8.10 grams (0.15 mole) of sodium methoxide in 200 milliliters of methanol was heated at reflux overnight. The resulting solution was acidified with concentrated hydrochloric acid and thereafter diluted with water. The solid 4-((6-methoxy-2-pyridyl)thio)phenol product was recovered by filtration, water washed and dried. The product was recovered in a yield of 10 grams (86 percent of theoretical) and melted at 88.5°-94.5° C.

Workup

  1. temperatureat reflux overnight
  2. filtrationThe solid 4-((6-methoxy-2-pyridyl)thio)phenol product was recovered by filtration, water
  3. washwashed
  4. customdried
  5. customThe product was recovered in a yield of 10 grams (86 percent of theoretical) and melted at 88.5°-94.5° C.

Sources & evidence

ORD record
ord-35d76e7aa8af4ad6a4d59ca1d8130f74
Source dataset
uspto-grants-1978_03
Patent number
US04080443

Reaction notes

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