(+-)-2-Butanol → HCID 12783677, compound

HRID 1679353Notes

Reaction equation

HRID 1679353 reaction equation
[Na].Cl[C:3]1[NH:8][C:7](=[O:9])[C:6]([F:10])=[CH:5][N:4]=1.[CH:11]([OH:15])([CH2:13][CH3:14])[CH3:12]>>[CH:11]([O:15][C:3]1[NH:8][C:7](=[O:9])[C:6]([F:10])=[CH:5][N:4]=1)([CH2:13][CH3:14])[CH3:12]

Participants

4

Reactant 3

HCID 6568(+-)-2-ButanolHCID 2553942-Chloro-5-fluoropyrimidin-4(3H)-oneHCID 5360545Sodium

Product 1

HCID 12783677HCID 12783677, compoundYield 91.4%

Procedure

A 300 ml quantity of absolute sec-butanol, 5.8 g of metal sodium and 14.9 g of 2-chloro-5-fluoropyrimidin-4-one are treated in the same manner as in Example 6 to obtain crystals, which are then recrystallized from a water-ethanol mixture to give 17.0 g of white crystalline 2-sec-butoxy-5-fluoropyrimidin-4-one in a yield of 91.4 %, m.p. 104°-105° C.

Workup

  1. customto obtain crystals, which
  2. customare then recrystallized from a water-ethanol mixture

Sources & evidence

ORD record
ord-5f3d97747372426a9060097a27d92d5b
Source dataset
uspto-grants-1978_03
Patent number
US04080455

Reaction notes

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