Hydrochloric Acid → HCID 20362678, compound

HRID 1679366Notes

Reaction equation

HRID 1679366 reaction equation
[C:1]([CH2:3][CH2:4][N:5]1[C:11](=[O:12])[CH:10]([CH3:13])[CH2:9][C:8]2[CH:14]=[CH:15][CH:16]=[CH:17][C:7]=2[CH2:6]1)#[N:2].Cl.C(=O)([O-])[O-:20].[Na+].[Na+]>O>[C:1]([CH2:3][CH2:4][N:5]1[C:11](=[O:12])[CH:10]([CH3:13])[CH2:9][C:8]2[CH:14]=[CH:15][CH:16]=[CH:17][C:7]=2[CH2:6]1)(=[O:20])[NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 20362666HCID 20362666, compound

Product 1

HCID 20362678HCID 20362678, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2.1 g. (0.0092 moles) of 2-(2-cyanoethyl)-4-methyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-one in 5 ml. of 35% hydrochloric acid is heated for 30 minutes at 40° C., while stirring. The reaction mixture is poured into 30 ml. of water and the pH adjusted to 9 by the addition of sodium carbonate, with vigorous stirring. The precipitate formed is washed with water, dried and then recrystallized from diisopropyl ether. 1.5 g. (66% of theory) of 2-(2-carbamoylethyl)-4-methyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-one is obtained. M.P. 168°-169° C.

Workup

  1. additionThe reaction mixture is poured into 30 ml
  2. customThe precipitate formed
  3. washis washed with water
  4. customdried
  5. customrecrystallized from diisopropyl ether

Sources & evidence

ORD record
ord-1c8de2792f2649d18932b6c92eb04c8a
Source dataset
uspto-grants-1978_03
Patent number
US04080449

Reaction notes

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