Acetone → HCID 20362892, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3,5-dichlorophenyl isocyanate (71.5 g.) in acetone (250 cc.), and triethylamine (38.4 g.) are added successively, whilst stirring, to a solution of 3-isopropyl-hydantoin (56.8 g.) in acetone (250 cc.). The temperature of the reaction mixture rises gradually from 25° C to 50° C over the course of 20 minutes and then again drops, whilst a copious precipitate forms. The reaction mixture is stirred for a further 5 hours at a temperature of about 20° C. The precipitate is filtered off, washed with acetone (2 × 50 cc.) and then dried under reduced pressure. 1-(3,5-Dichlorophenyl)-carbamoyl-3-isopropyl-hydantoin (100 g.) melting at 200° C, is thus obtained.

Provenance & Evidence