Ethanolamine → HCID 178506611, compound

HRID 1679487Notes

Reaction equation

HRID 1679487 reaction equation
[IH:1].CS[C:4]1[NH:5][CH2:6][CH:7]([C:9]2[C:14]([Cl:15])=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:16])[N:8]=1.[CH2:17]([CH2:19][NH2:20])[OH:18].CCOCC>C(O)C>[IH:1].[OH:18][CH2:17][CH2:19][NH:20][C:4]1[NH:5][CH2:6][CH:7]([C:9]2[C:14]([Cl:15])=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:16])[N:8]=1

Participants

5

Reactant 3

HCID 700EthanolamineHCID 3283Diethyl EtherHCID 178503392HCID 178503392, compound

Product 1

HCID 178506611HCID 178506611, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
130 °C

Procedure

5.0 gm (0.0129 mol) of 2-methylmercapto-4-(2',6'-dichloro-phenyl)-2-imidazoline hydroiodide and 7.9 gm (0.13 mol) of ethanolamine were dissolved in 30 ml of ethanol, and the solution was heated in an autoclave for 3 hours at 130° C. Thereafter, the reaction solution was cooled and then admixed with ether, and the crystals precipitated thereby were collected, washed with acetone and recrystallized from ethanol/ether, yielding 1.5 gm (29% of theory) of the pure compound of the formula ##STR14##

Workup

  1. temperatureThereafter, the reaction solution was cooled
  2. customthe crystals precipitated
  3. customthereby were collected
  4. washwashed with acetone
  5. customrecrystallized from ethanol/ether
  6. customyielding 1.5 gm (29% of theory) of the pure compound of the formula

Sources & evidence

ORD record
ord-ebd53bd02c9a4982b0609894ed580678
Source dataset
uspto-grants-1978_03
Patent number
US04080503

Reaction notes

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