Sodium Hydroxide → HCID 23695280, compound

HRID 1679507Notes

Reaction equation

HRID 1679507 reaction equation
[Cl:1][CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]([CH3:25])([CH3:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+:27]>C(O)C.O>[Cl:1][CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]([CH3:25])([CH3:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:11][CH:10]=1)[C:3]([O-:5])=[O:4].[Na+:27]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 194150Ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropoxy)phenyl]propanoate

Product 1

HCID 23695280HCID 23695280, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

In 15 ml of ethanol is dissolved 3.6 g of ethyl 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)phenyl]propionate, and under cooling with ice and stirring, a solution of 0.35 sodium hydroxide in 3.5 ml water is added. The mixture is kept under the same condition for 30 minutes, after which the solution is concentrated to dryness. The residue is dissolved in 10 ml of water, the solution is washed three times with ether, and then the solution is concentrated to dryness. The procedure yields 2.6 g of sodium 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)-phenyl]propionate, as white amorphous substance.

Workup

  1. temperatureunder cooling with ice
  2. concentrationafter which the solution is concentrated to dryness
  3. dissolutionThe residue is dissolved in 10 ml of water
  4. washthe solution is washed three times with ether
  5. concentrationthe solution is concentrated to dryness

Sources & evidence

ORD record
ord-c61f1f2068714e40af99166812fd33ab
Source dataset
uspto-grants-1978_03
Patent number
US04080505

Reaction notes

Loading…