Sodium Hydroxide → HCID 23695280, compound

Participants

Reaction Steps

In 15 ml of ethanol is dissolved 3.6 g of ethyl 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)phenyl]propionate, and under cooling with ice and stirring, a solution of 0.35 sodium hydroxide in 3.5 ml water is added. The mixture is kept under the same condition for 30 minutes, after which the solution is concentrated to dryness. The residue is dissolved in 10 ml of water, the solution is washed three times with ether, and then the solution is concentrated to dryness. The procedure yields 2.6 g of sodium 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)-phenyl]propionate, as white amorphous substance.

Provenance & Evidence