Ethylene Glycol → HCID 178418543, compound

HRID 1679544Notes

Reaction equation

HRID 1679544 reaction equation
C(C1[C:4](=[O:9])[NH:5][CH:6]=[CH:7][CH:8]=1)#N.[OH-:10].[K+].[CH2:12]([OH:15])[CH2:13]O>O>[OH:9][C:4]1[N:5]=[CH:6][CH:7]=[CH:8][C:13]=1[C:12]([OH:15])=[O:10]

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 14797Potassium HydroxideHCID 5775433-Cyano-2-pyridone

Product 1

HCID 178418543HCID 178418543, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepare a solution containing 6 g of 3-cyano-2-pyridone, 7.5 g of potassium hydroxide pellets (85%), 8 ml. of ethylene glycol and 1.5 ml. of water. Heat the solution to 150°-160° C for 15 minutes and pour the reaction mixture into ice water. Acidify the aqueous solution to a pH of about 3. The 2-hydroxy-nicotinic acid precipitates, is collected by filtration and dried yielding the product of this step, m.p. 258°-260° C.

Workup

  1. customPrepare a solution
  2. temperatureHeat the solution to 150°-160° C for 15 minutes
  3. customThe 2-hydroxy-nicotinic acid precipitates
  4. filtrationis collected by filtration
  5. customdried
  6. customyielding the product of this step, m.p. 258°-260° C.

Sources & evidence

ORD record
ord-5930d197e19a4385b5de2191007bfdc0
Source dataset
uspto-grants-1978_03
Patent number
US04081451

Reaction notes

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