反应详情

Prepare a solution containing 6 g of 3-cyano-2-pyridone, 7.5 g of potassium hydroxide pellets (85%), 8 ml. of ethylene glycol and 1.5 ml. of water. Heat the solution to 150°-160° C for 15 minutes and pour the reaction mixture into ice water. Acidify the aqueous solution to a pH of about 3. The 2-hydroxy-nicotinic acid precipitates, is collected by filtration and dried yielding the product of this step, m.p. 258°-260° C.

1. customPrepare a solution
2. temperatureHeat the solution to 150°-160° C for 15 minutes
3. customThe 2-hydroxy-nicotinic acid precipitates
4. filtrationis collected by filtration
5. customdried
6. customyielding the product of this step, m.p. 258°-260° C.