Hydrazine hydrate (1:1) → 1-[(aminooxy)methyl]-8-nitro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

HRID 1679587Notes

Reaction equation

HRID 1679587 reaction equation
O.NN.[N+:4]([C:7]1[CH:8]=[CH:9][C:10]2[N:16]3[C:17]([CH2:20][O:21][N:22]4C(=O)C5=CC=CC=C5C4=O)=[N:18][N:19]=[C:15]3[CH2:14][N:13]=[C:12]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[Cl:39])[C:11]=2[CH:40]=1)([O-:6])=[O:5]>C(O)C>[NH2:22][O:21][CH2:20][C:17]1[N:16]2[C:10]3[CH:9]=[CH:8][C:7]([N+:4]([O-:6])=[O:5])=[CH:40][C:11]=3[C:12]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[Cl:39])=[N:13][CH2:14][C:15]2=[N:19][N:18]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 203612598-nitro-1-[(phthalimidooxy)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 203611581-[(aminooxy)methyl]-8-nitro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 2, a solution of hydrazine hydrate in ethanol is reacted at 65° C. with 8-nitro-1-[(phthalimidooxy)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 1-[(aminooxy)methyl]-8-nitro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-0b808fdc159a4dbb8ddd5311abe101cb
Source dataset
uspto-grants-1978_03
Patent number
US04081452

Reaction notes

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