Hydrazine hydrate (1:1) → 8-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

HRID 1679591Notes

Reaction equation

HRID 1679591 reaction equation
O.NN.[Br:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[C:15](CON4C(=O)C5=CC=CC=C5C4=O)=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)[C:9]=2[CH:37]=1>C(O)C>[Br:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[CH:15]=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)[C:9]=2[CH:37]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 203611848-bromo-1-[(phthalimidooxy)methyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 125625168-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 2, a solution of hydrazine hydrate in ethanol is reated at 65° C. with 8-bromo-1-[(phthalimidooxy)methyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 1-(aminooxy)methyl]-8-bromo-6-(2pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-22313a1309984a0f81e0025bfd65cb98
Source dataset
uspto-grants-1978_03
Patent number
US04081452

Reaction notes

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