Piperidine → HCID 20361138, compound

HRID 1679648Notes

Reaction equation

HRID 1679648 reaction equation
[CH3:1][O:2][C:3](=[O:9])[CH2:4][CH2:5][CH2:6][CH2:7]I.[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>C1C=CC=CC=1>[N:10]1([CH2:7][CH2:6][CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:9])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 334445methyl 5-iodopentanoate

Product 1

HCID 20361138HCID 20361138, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

30.0 g. (0.124 mole) of methylδ-iodovalerate and 42.5 g. (0.50 mole) of piperidine are dissolved in 250 ml. of benzene and heated at 60° C. for 3 hours with stirring. A colorless solid begins to appear shortly after the materials are combined. The solid is removed by suction filtration, and the benzene evaporated to give methyl δ-piperidinovalerate which distills as 23.5 g. (95%) of colorless liquid, b.p., 122°-24° C. (12.5 mm.).

Workup

  1. customThe solid is removed by suction filtration
  2. customthe benzene evaporated

Sources & evidence

ORD record
ord-d390ff2dd7cc45c0ae74ce9dfd1baa97
Source dataset
uspto-grants-1978_03
Patent number
US04081449

Reaction notes

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