Hydrochloric Acid → 5-(Piperidin-1-yl)pentanoic acid hydrochloride

HRID 1679649Notes

Reaction equation

HRID 1679649 reaction equation
C[O:2][C:3](=[O:14])[CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[ClH:15]>O>[ClH:15].[N:8]1([CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:14])=[O:2])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20361138HCID 20361138, compound

Product 1

HCID 545927615-(Piperidin-1-yl)pentanoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

23.5 g. (0.117 mole) of methylδ-piperidinovalerate is dissolved in a combination of 125 ml. of concentrated hydrochloric acid and 125 ml. of water and refluxed with stirring for 16 hours. The excess water is removed using reduced pressure (water aspirator) to give a semi-solid residue which is triturated with acetone, filtered and dried. 21.0 g. (79%) of colorless crystals of δ-piperidinovaleric acid hydrochloride are obtained, m.p. of 202°-204° C.

Workup

  1. customThe excess water is removed
  2. customto give a semi-solid residue which
  3. customis triturated with acetone
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-4714512a025e4a198ba577745d78b338
Source dataset
uspto-grants-1978_03
Patent number
US04081449

Reaction notes

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