反应详情

23.5 g. (0.117 mole) of methylδ-piperidinovalerate is dissolved in a combination of 125 ml. of concentrated hydrochloric acid and 125 ml. of water and refluxed with stirring for 16 hours. The excess water is removed using reduced pressure (water aspirator) to give a semi-solid residue which is triturated with acetone, filtered and dried. 21.0 g. (79%) of colorless crystals of δ-piperidinovaleric acid hydrochloride are obtained, m.p. of 202°-204° C.

1. customThe excess water is removed
2. customto give a semi-solid residue which
3. customis triturated with acetone
4. filtrationfiltered
5. customdried