HRID1679656

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：CCCC(C)(c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(Cc2ccccc2)CC1)c1cc(Cl)ccc1C

HCID54170042

未命名化合物

HCID70565727

未命名化合物

PRODUCTS

生成物

结构：CCCC(C)(c1cc(OC(=O)CCCN2CCCCC2C)c2c(c1)OC(C)(C)C1=C2CN(Cc2ccccc2)CC1)c1cc(Cl)ccc1C.Cl

HCID70623667

未命名化合物

PROCEDURE

实验过程

2-Benzyl-5,5-dimethyl-10-hydroxy-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine, γ-(2-methylpiperidino)-butyric acid hydrochloride and dicyclohexylcarbodiimide in equimolar amounts are reacted as in Example 7 to give the desired product.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0f87534a1b684ecea8e2369ac8bc2b00
来源数据集: uspto-grants-1978_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04081449
来源说明: uspto-grants-1978_03

反应 SMILES

[CH2:1]([N:8]1[CH2:13][C:12]2[C:14]3[C:23]([OH:24])=[CH:22][C:21]([C:25]([C:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=4[CH3:37])([CH3:29])[CH2:26][CH2:27][CH3:28])=[CH:20][C:15]=3[O:16][C:17]([CH3:19])([CH3:18])[C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:39][CH:40]1[CH2:45][CH2:44][CH2:43][CH2:42][N:41]1[CH2:46][CH2:47][CH2:48][C:49](O)=[O:50].C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:36].[CH2:1]([N:8]1[CH2:13][C:12]2[C:14]3[C:23]([O:24][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][N:41]4[CH2:42][CH2:43][CH2:44][CH2:45][CH:40]4[CH3:39])=[CH:22][C:21]([C:25]([C:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=4[CH3:37])([CH3:29])[CH2:26][CH2:27][CH3:28])=[CH:20][C:15]=3[O:16][C:17]([CH3:18])([CH3:19])[C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1