Dicyclohexylcarbodiimide → 2-Benzyl-5,5-dimethyl-10-[4-(2-methylpiperidino)butyryloxy]-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Dicyclohexylcarbodiimide	HCID 10868	—
Reactant	2-Benzyl-5,5-dimethyl-10-hydroxy-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine	HCID 54170042	—
Reactant	4-(2-Methylpiperidin-1-yl)butanoic acid hydrochloride	HCID 70565727	—
Product	2-Benzyl-5,5-dimethyl-10-[4-(2-methylpiperidino)butyryloxy]-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine hydrochloride	HCID 70623667	—

Reaction Steps

2-Benzyl-5,5-dimethyl-10-hydroxy-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine, γ-(2-methylpiperidino)-butyric acid hydrochloride and dicyclohexylcarbodiimide in equimolar amounts are reacted as in Example 7 to give the desired product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04081449
Source dataset	uspto-grants-1978_03
ORD ID	ord-0f87534a1b684ecea8e2369ac8bc2b00
Source note	uspto-grants-1978_03