HCID 178469693, compound → HCID 178524739, compound

HRID 1679683Notes

Reaction equation

HRID 1679683 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13]CC)=[O:12]>Cl>[OH:1][C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([OH:13])=[O:12]

Participants

3

Reactant 1

HCID 178469693HCID 178469693, compound

Product 1

HCID 178524739HCID 178524739, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of ethyl 7-hydroxy-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxylate (5.6g. 25mM) and 2N hydrochloric acid (40ml) was heated under reflux for 5 hours. The reaction mixture was cooled and filtered to give the required product in 67.3% weight yield (3.30g). m.p. 296° C (decomposition). νmax (KBr disc) 1725 (acid C=O)cm-1 ; λmax (NaHCO3 solution) 293nm (εm 14,900); (Found: C, 40.27; H, 2.35; N, 30.49%. C6H4N4O3 requires C, 40.01; H, 2.24; N, 31.10%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered

Sources & evidence

ORD record
ord-01cbbb092b5949fe93d23cc3b7eb14ab
Source dataset
uspto-grants-1978_03
Patent number
US04081545

Reaction notes

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