Pyridine → HCID 86735573, compound

HRID 1679688Notes

Reaction equation

HRID 1679688 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH2:10][CH2:11][CH2:12][C:13]#[N:14])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.Cl.[NH2:18][O:19][CH2:20][CH2:21][NH2:22].N1C=CC=CC=1>C(O)C>[ClH:1].[NH2:22][CH2:21][CH2:20][O:19][N:18]=[C:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:10][CH2:11][CH2:12][C:13]#[N:14]

Participants

5

Reactant 3

HCID 1049PyridineHCID 143623262-(O-aminooxy)ethylamine dihydrochlorideHCID 70627006HCID 70627006, compound

Product 1

HCID 86735573HCID 86735573, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 6.9 mmol (1.67 g) of 3', 4'-dichloro-4-cyanobutyrophenone (melting point 53°-54° C), 6.9 mmol (1.03 g) of 2-aminooxyethylamine dihydrochloride, 6.9 mmol (0.56ml) of pyridine and 5 ml of absolute ethanol was refluxed for 3.5 hours.

Workup

  1. temperaturewas refluxed for 3.5 hours

Sources & evidence

ORD record
ord-ebdf1b6059554d28af7a35e2b381254f
Source dataset
uspto-grants-1978_03
Patent number
US04081552

Reaction notes

Loading…